The Human Effect Matrix summarizes human studies to tell you what effects Agmatine has on your body, how much evidence there is, and how strong these effects are. To unlock the full archives of our Study Database and research analyses, become an Examine Member today. Clonidine-displacing substance, 4- aminobutyl guanidine, Decarboxylated arginine.
L-Arginine parent structure. Cannabinoids such as marijuana as agmatine enhances signalling through the cannabinoid CB1 receptor. Alcohol withdrawal appears to reduce symptoms. Although at this moment in time agmatine appears to be pretty nontoxic, there is insufficient toxicology testing for superloading. It may be prudent to stick within the 2,mg dosage that has been used in humans.
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This page is regularly updated, to include the most recently available clinical trial evidence. Research analysis led by Kamal Patel and reviewed by the Examine team. Last Updated: Oct 5, Summary of Agmatine Primary information, health benefits, side effects, usage, and other important details.
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Get instant access — start your free day trial Already a Member? Click here to log in. Full details are available to Examine Members. Not a Member? Try Examine Membership completely free for two weeks. Grade Level of Evidence [show legend] Robust research conducted with repeated double-blind clinical trials Multiple studies where at least two are double-blind and placebo controlled Single double-blind study or multiple cohort studies Uncontrolled or observational studies only.
Level of Evidence? The amount of high quality evidence. The more evidence, the more we can trust the results. The direction and size of the supplement's impact on each outcome.
Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect. These studies have ushered in the use of dietary agmatine as a nutraceutical. However, in view of information paucity, assessment of long-term safety of oral agmatine treatment is now clearly required.
The authors of this report undertook to assess their own health status during ongoing consumption of a high daily dosage of oral agmatine over a period of years. A daily dose of 2. Clinical follow-up consists of periodic physical examinations and laboratory blood and urine analyses. All measurements thus far remain within normal values and good general health status is sustained throughout the study period, up to 5 years. This case study shows for the first time that the recommended high dosage of agmatine may be consumed for at least 5 years without evidence of any adverse effects.
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